Applications for measuring redox potential

Understanding a patient’s redox balance is a highly important assessment that is currently being studied in varying phases of pre-clinical, translational, and clinical research.

Listed below are some of the many validated and implicated redox imbalance-mediated diseases and conditions where measuring redox potential (also called oxidation-reduction potential or ORP) could help clinical researchers advance knowledge so they are better able to1:

  • Assess disease severity
  • Evaluate effect of therapeutics
  • Make prognostic assessments, including risk of developing more aggressive or severe disease

A patient is rushed to the ER with a traumatic brain injury. Getting a complete and accurate picture of the severity of the injury is critical. Imagine if the severity and prognosis could be easily assessed by measuring redox potential to differentiate the degree of redox imbalance.

Validated

  • Isolated traumatic brain injury (iTBI)
  • Liver disease
  • Multitrauma injury
  • Stroke

Implicated

  • Acute and chronic kidney disease and hemodialysis
  • Acute Coronary Syndrome
  • Adrenoleukodystrophy
  • Aging
  • Astherosclerosis
  • Cancer
  • Cardiovascular disease (eg, pulmonary arterial hypertension)
  • Chronic obstructive pulmonary disease (COPD)
  • Congestive Heart Failure
  • Diabetes mellitus
  • Diabetic Kidney Disease
  • Exercise induced oxidized stress
  • Frailty
  • GI
  • Hip Fracture
  • Immune-mediated diseases (eg, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus)
  • Lichen sclerosus (LS)
  • Neurodegenerative diseases (eg, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis)
  • Sepsis
  • SIRS
  • Sickle Cell Disease
  • Spinal Cord Injury
  • Transfusion
  • Transplant
  • Ventilator-associated pneumonia (VAP)
The clinical validity of measuring redox potential has been established in assessing critically injured
patients.1-3