Scientific evidence

VALIDATED CLINICAL RESEARCH

The clinical utility of redox potential (also called oxidation-reduction potential or ORP) has been validated by select researchers in multiple peer-reviewed publications:

 

The clinical utility of ORP has been presented at various scientific meetings including the following podium presentations and posters:

  • Oxidation-reduction potential (ORP) as a rapid, easy, and reliable biomarker for traumatic brain injury. Kimberly B. Bjugstad, Stewart Levy, Matthew Carrick, Charles W Mains, Deneta S. Slone, David Bar-Or, (March 2016) World Congress on Brain Injury; March 2016, the Hague, NL. (podium)
  • A New Method to Assess Oxidative Stress (OS) Changes Induced by One Hemodialysis Session. Shifra Sela, Ronit Geron, Galina Shapiro, Elisheva Milo, Kimberly Bjugstad, Raphael Bar-Or, David Bar-Or, and Batya Kristal. (November 2015) Society for Redox Biology and Medicine, Boston MA (poster)
  • Time course of redox potential and antioxidant capacity in patients undergoing cardiac Surgery. Christian Stoppe, Sandra Kraemer, Carina Benstoem, Gereon Schaelte, David Bar-Or, Andreas Goetzenich (March 2015). International Symposium On Intensive Care And Emergency Medicine, Brussels, Belgium (poster).
  • A Novel Method for Measuring Oxidative Stress in Patients with Stroke Symptoms. JC Wagner, K Salottolo, CV Fanale, M Whaley, KL McCarthy, D Bar-Or (April 2015). American Academy of Neurology, Washington, D.C. (podium).
  • A Novel Method for Measuring Oxidative Stress in Patients with Stroke Symptoms. JC Wagner, K Salottolo, CV Fanale, M Whaley, KL McCarthy, D Bar-Or (February 2015). International Stroke Conference, Nashville, TN (poster).
  • Development of a New Method for Assessing Redox Status in Humans: Application in Strenuous Exercise-Induced Oxidative Stress. Stagos D, Goutzourelas N, Bar-Or, D, Orlando A, Ntontou AM, Bella E, Becker AT, Statiri AT, Kouretas D (November 2014). 21st Annual Meeting of the Society for Free Radical Biology and Medicine, Seattle, WA (poster).
  • Assessment of catalytic activity and oxidation-reduction potential of custom-synthesized cerium oxide nanoparticles in cell-free systems and brain tissue. Ana Y. Estevez, Sierra Miller, Quinn Self and Joseph. S. Erlichman (November 2014). Society for Free Radical and Biologic Medicine, Seattle, WA (poster).
  • Assessment of Oxidative Stress and Antioxidant Therapy via Oxidation-Reduction Potential in a Mouse Model of Parkinson’s Disease. L Caputo, C Beyer, M Neary, M Zigmond, S Castro, D Bar-Or (November 2014). Society for Free Radical and Biologic Medicine, Seattle, WA (poster).
  • Significant differences in oxidative stress between healthy controls and TBI patients: A 5-year multicenter prospective observational cohort study. A Orlando, L Rael, R Bar-Or, DS Slone CW Mains, D Bar-Or (September 2014). American Association for the Surgery of Trauma, Philadelphia, PA (poster).

ONGOING RESEARCH

Global Research Collaborations

  • Oxidation-reduction potential as a biomarker in a Parkinson’s disease model (U.S. pharmaceutical company)
  • Oxidation-reduction potential as a biomarker in neurodegenerative disease drug development (U.S. pharmaceutical company)
  • Oxidative monitoring of ICU patients using oxidation-reduction potential as a biomarker (University Hospital, Larissa, Greece)
  • A controlled study to assay an increase in oxidative stress by using a model of hypertension (Eliachar Research Laboratory, Nahariya, Israel)
  • Changes in oxidative stress as measured by oxidation-reduction potential after one dialysis session with and without IV iron (Western Galilee Hospital, Nahariya, Israel)
  • Oxidation-reduction potential as a marker of oxidative stress before and after strenuous physical exertion (University of Thessaly, Volos, Greece)
 

Ongoing Internal Research

  • Oxidation-reduction potential as a prognostic marker following isolated traumatic brain injury (iTBI)
  • Oxidation-reduction potential as a prognostic marker in the assessment of congestive heart failure
  • Oxidation-reduction potential as a prognostic marker following stroke
  • Oxidation-reduction potential as a prognostic marker in the assessment of elderly frailty
  • Oxidation-reduction potential as a prognostic marker following pelvic fractures in elderly patients