Why current methods of assessing redox status are inadequate

While redox imbalance has been widely studied in multiple research settings, it has not been possible to accurately, easily, and completely assess a patient’s overall redox status in real time.

Surrogate markers have historically been used to measure redox imbalance in patients (eg, antioxidants like glutathione, lipid peroxidation, free radical production, protein oxidation, and/or enzyme activity).1,5 Relying upon measurements of individual markers often results in an unreliable, variable, and conflicting measurement of a patient’s redox balance. Other limitations include that they1,2:

  • Are unable to provide sufficient diagnostic value on their own
  • Do not provide a complete picture of redox imbalance and miss other important factors that contribute to a patient’s overall redox balance

Researchers evaluating exercise-induced oxidative stress in marathon runners, identified higher sORP, TBAR, and protein carbonyl levels in runners after the race, indicating oxidative stress induction.

Measuring individual reactive oxygen species provides an isolated picture of oxidation

Oxidation diagram showing individual oxygen species

Electrochemical devices

Redox potential of blood, and blood products, can also be measured by standard reusable electrochemical immersion probes. They previously were inconvenient and poorly suited for routine clinical diagnostic testing because they typically require:

  • Large sample volumes (10 to hundreds of milliliters)
  • Long equilibrium periods
  • Cleaning of large, bulky electrodes between sample measurements
Meeting the need
for easy and complete measurement

With the RedoxSYS® System, redox potential from a blood sample can now be accurately, easily, and completely measured in real time without requiring large samples, long equilibrium periods, or bulky electrodes that need to be cleaned. It is the first and only research platform that provides a homeostatic measurement of redox imbalance resulting from a critical injury or illness.

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