What is Redox potential?

Redox potential (also called oxidation-reduction potential or ORP) is an integrated measure of the balance between total oxidants and total reductants in a biological system, such as the human body.3

The value of this measurement is that it provides an overall picture of all of the known and unknown elements that generate redox imbalance. Researchers widely agree that redox imbalance plays a crucial role in numerous medical conditions.1-4

Generation of Redox Imbalance

Researchers studying the deterioration of the dopaminergic cells, are investigating whether a new antioxidant compound will attenuate oxidative stress and slow progression of Parkinson’s disease.

Reactive oxygen species and redox imbalance

Redox imbalance is caused by a higher production of reactive oxygen species (ROS) and reactive nitrogen species or a decrease in endogenous protective antioxidants. These antioxidant defenses are important for removing free radicals.4

ROS can initiate cellular tissue damage by modifying lipids, proteins, and DNA. This can seriously compromise cell health and viability. It can also create a cascade of cellular responses that can ultimately result in cell death by necrosis or apoptosis.4 Increased redox imbalance caused by overproduction of ROS is typical in a variety of medical conditions, including critical illnesses.1

ROS (eg, oxidized thiols, superoxide radical, hydroxyl radical, hydrogen peroxide, nitric oxide, peroxynitrite, and transition metal ions) can be scavenged by both metalloenzymes (eg, glutathione peroxidase, catalase, and superoxide dismutase) and non-enzymatic antioxidants (eg, glutathione, tocopherol, β-carotene, ubiquinol, vitamin C, lipoic acid, and uric acid).1,5 Simply attempting to scavenge ROS with therapeutics (such as antioxidants) — without a complete picture of redox imbalance — may be potentially harmful to patients.1

Assessing redox levels is suggested to help guide therapy and improve patient outcomes.

Examples of oxidants and reductants

OxidantsOxidized thiols, superoxide radical, hydroxyl radical, hydrogen peroxide, nitric oxide, and transition metal ions
ReductantsFree thiols, glutathione, lipoic acid, ascorbate, α-tocopherol, β-carotene, and uric acid

Redox imbalance and inflammation

Redox imbalance is often a marker of inflammation, which indicates the presence of disease-related processes or developing conditions across a myriad of acute and chronic disease areas.4 The ability to easily and completely measure redox balance in real time would be incredibly helpful to assess baseline status, as well as progression of redox imbalance-mediated diseases and conditions. Unfortunately, conventional methods of measuring redox balance are incomplete, time consuming, and impractical in a laboratory setting. Read more
Free radical redox imbalance diagram
An oxidation-reduction system, or redox reaction, involves the transfer of electrons from a reductant to an oxidant.2 Read more

Broad scientific and clinical research utility

Numerous scientific studies point to the research value of measuring redox potential to address redox imbalance. It could provide critical information and advance understanding at every level of research1 for:

Meeting the need for complete measurement of redox potential

Redox potential from a blood sample can be accurately, easily, and completely measured in real time with the RedoxSYS® System, the first and only research platform that provides a homeostatic measurement of redox imbalance that results from a medical condition.

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